Growth Factors in Cosmetic Medicine
Why? When? Which product?
Skin rejuvenation treatments have evolved significantly, offering a range of options for those seeking to combat signs of aging.
Growth factors have emerged as a powerful tool in cosmetic medicine, recommended for their ability to stimulate cellular regeneration and enhance the skin’s natural healing processes.
They are typically suggested when patients seek advanced anti-aging solutions or wish to improve overall skin quality and texture.
The purpose of using growth factors is to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles.
Growth factors are often combined with other treatments to amplify their effectiveness. For instance, when used in conjunction with microneedling, laser resurfacing, or fractional resurfacing, growth factors can penetrate deeper into the skin, leading to more profound and lasting results.
This combination approach is particularly beneficial for addressing multiple skin concerns simultaneously, such as photoaging, uneven texture, and loss of firmness.
By integrating growth factors with other cosmetic procedures, we aim to accelerate healing, minimize downtime, and achieve more dramatic improvements in skin appearance and health.
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Exosomes
Exosomes are tiny vesicles released by cells that contain growth factors, proteins, and genetic material. In skincare, they are typically derived from stem cells.
How it works:
– Act as messengers between cells
– Stimulate skin regeneration and reduce inflammation
– Work at a cellular level for profound effects
Best for:
– Hair loss solutions
– Skin rejuvenation
– Improving texture and tone
– Reducing inflammation and promoting healing
– Reduce fine lines and wrinkles
– Improve skin firmness
– Decrease redness
Treatment Process
Exosome facials are typically performed as follows:
- Often combined with microneedling or laser therapy to enhance penetration
- Exosome serum is applied to the skin
- Treatment takes 1-2 hours
- No downtime required
Results and Effectiveness
– Initial improvements may be visible in 2 weeks
– Full effects typically seen 6-8 weeks post-treatment
– Results can last 6 months to 2 years
– Generally considered safe with minimal side effects
– Temporary redness may occur for up to 2 days
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Polynucleotides (PN)
Polynucleotides (PN) have emerged as an innovative treatment for facial rejuvenation, offering several benefits.
They are molecules typically derived from salmon DNA and act as biostimulators when injected into the skin. They are highly purified and biocompatible with human DNA.
Benefits for Facial Rejuvenation:
– Reduce fine lines and wrinkles
– Improve skin texture and firmness
– Enhance collagen and elastin production
– Even out skin tone
– Increase skin hydration
– Decrease inflammation and rednes-
Promote overall skin rejuvenation and repair
Treatment Process
A typical PN treatment involves:
- Multple small injections into the dermis
- Treatment sessions spaced 2-3 weeks apart
- An initial course of 3 treatments
- Maintenance treatments every 6-12 months
Results and Effectiveness
– Initial improvements may be visible within weeks
– Full effects typically seen after completing the initial treatment course
– Results can last several months, with ongoing maintenance
Comparison to Other Treatments
Polynucleotides offer some advantages over other rejuvenation treatments:
– More natural and gradual results compared to dermal fillers
– Potential for longer-lasting effects than some other skin boosters
– Can be combined with other treatments for enhanced results
– Generally considered safe with minimal side effects
– Temporary redness, swelling, or bruising may occur
– Suitable for most people, including those with fish allergies
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Platelet-Rich Fibrin (PRF)
PRF is an advanced version of PRP, processed differently to preserve more beneficial components[.
How it works:
– Blood is centrifuged at lower speed
– No anticoagulants added, forming a fibrin matrix
– Growth factors release slowly over about a week
Best for:
– Addressing deeper wrinkles
– Building skin volume
– Enhancing overall rejuvenation
– Boosting hair and scalp health
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Platelet-Rich Plasma (PRP)
PRP is derived from your own blood and contains concentrated platelets that release growth factors.
How it works:
– Blood is drawn and processed in a centrifuge
– Platelet-rich plasma is separated and injected
– Growth factors are released for a few hours
Best for:
– Improving skin texture and tone
– Reducing fine lines
– Treating acne scars
– Promoting hair growth
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EzGel
EzGel is an innovative treatment that combines platelet-rich fibrin (PRF) and plasma into a gel that creates a natural filler and biostimulator:
– A 100% natural gel made from components of the patient’s own blood
– Combines platelet-rich fibrin, plasma albumin, and growth factors
– Acts as both a filler and a biostimulator
Main Indications
EzGel can be used to treat various facial areas, including:
– Under-eye hollows
– Nasolabial folds
– Marionette lines
– Lips
– Cheeks
– Chin and jawline
– Fine lines and wrinkles
– Overall skin rejuvenation
How It Compares to Other Treatments
Compared to traditional dermal fillers:
– More natural, using patient’s own cells
– Lower risk of allergic reactions
– Provides both immediate volumizing and long-term regenerative effects
– Results can last 6 months to 2 years
Compared to PRP/PRF:
– Longer-lasting effects due to gel consistency
– Provides more immediate volumizing in addition to regenerative benefits
– Can be precisely injected like a dermal filler
Compared to other biostimulators:
– 100% autologous, reducing risk of side effects
– Combines filling and biostimulation in one treatment
– More versatile in terms of treatment areas
Key Benefits
– Natural-looking results
– Stimulates collagen and elastin production
– Improves skin texture and tone
– Minimal downtime
– Can be combined with other treatments
– Customizable to patient needs
Effectiveness Comparison of Different Products:
| Treatment | Effectivness | Best Applications |
| Exosomes | Highest | Overall rejuvenation, wound healing, pigmentation, hair re-growth |
| Polynucleotides | High | Skin repair, inflammation, texture improvement, Acne, rosacea, scars |
| PRF | Moderately High | Hair re-growth, volume building, deeper wrinkles |
| PRP | Moderate | Fine lines, general skin quality |
Exosomes appear to be the most promising, containing a higher concentration and diversity of growth factors.
Polynucleotides are highly effective for repairing damaged skin and improving texture.
PRF offers sustained release of growth factors, potentially more effective for deeper wrinkles than PRP. PRP, while widely used, may be less effective than newer options but still improves overall skin quality.
The choice of treatment depends on specific skin concerns, desired outcomes, and individual factors.
In our clinic we are using all these growth factors and we welcome any enquiries and expressions of interest.
